PTPRCAP

PTPRCAP
Identifiers
Aliases	PTPRCAP, CD45-AP, LPAP, protein tyrosine phosphatase, receptor type C associated protein, protein tyrosine phosphatase receptor type C associated protein
External IDs	OMIM: 601577; MGI: 97811; HomoloGene: 48358; GeneCards: PTPRCAP; OMA:PTPRCAP - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,437,682 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,206,750 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; blood; ; lymph node; ; appendix; ; mucosa of transverse colon; ; bone marrow cells; ; gonad; ; right uterine tube; ; duodenum;
	Top expressed in
	thymus; ; spleen; ; bone marrow; ; granulocyte; ; jejunum; ; ileum; ; colon; ; pharynx; ; lung; ; morula;
	More reference expression data
	n/a
Orthologs
	5790
	19265
	ENSG00000213402
	ENSMUSG00000045826
	Q14761
	Q64697
	NM_005608
	NM_016933
	NP_005599
	NP_058629
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase receptor type C-associated protein is an enzyme that in humans is encoded by the PTPRCAP gene.^[5]

The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045826 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein".

Schraven B, Schoenhaut D, Bruyns E, Koretzky G, Eckerskorn C, Wallich R, Kirchgessner H, Sakorafas P, Labkovsky B (1994). "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes". J. Biol. Chem. 269 (46): 29102–11. doi:10.1016/S0021-9258(19)62018-1. PMID 7961877.
Bruyns E, Hendricks-Taylor LR, Meuer S, Koretzky GA, Schraven B (1996). "Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45". J. Biol. Chem. 270 (52): 31372–6. doi:10.1074/jbc.270.52.31372. PMID 8537410.
Bruyns E, Mincheva A, Bruyns RM, Kirchgessner H, Weitz S, Lichter P, Meuer S, Schraven B (1997). "Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes". Genomics. 38 (1): 79–83. doi:10.1006/geno.1996.0595. PMID 8954783.
Kung C, Okumura M, Seavitt JR, Noll ME, White LS, Pingel JT, Thomas ML (2000). "CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction". Eur. J. Immunol. 29 (12): 3951–5. doi:10.1002/(SICI)1521-4141(199912)29:12<3951::AID-IMMU3951>3.0.CO;2-9. PMID 10602003. S2CID 4962507.
Woods ML, Kivens WJ, Adelsman MA, Qiu Y, August A, Shimizu Y (2001). "A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor". EMBO J. 20 (6): 1232–44. doi:10.1093/emboj/20.6.1232. PMC 145515. PMID 11250890.
Kirchgessner H, Dietrich J, Scherer J, Isomaki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vogel A, Strassburg CP, Manns MP (2003). "77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link". Genes Immun. 4 (1): 79–81. doi:10.1038/sj.gene.6363918. PMID 12595907. S2CID 19853676.
Cocco E, Murru MR, Melis C, Schirru L, Solla E, Lai M, Rolesu M, Marrosu M (2004). "PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients". J. Neurol. 251 (9): 1085–8. doi:10.1007/s00415-004-0485-1. PMID 15372250. S2CID 35718298.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213402 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045826 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein".

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References

Further reading