PURG

PURG
Identifiers
Aliases	PURG, PURG-A, PURG-B, purine-rich element binding protein G, purine rich element binding protein G, PURGA, PURGB
External IDs	OMIM: 618041; MGI: 1922279; HomoloGene: 22747; GeneCards: PURG; OMA:PURG - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p12 Start 30,995,802 bp End 31,033,715 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A3 Start 33,876,353 bp End 33,907,495 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm middle temporal gyrus Brodmann area 23 endothelial cell cerebellar vermis entorhinal cortex postcentral gyrus internal globus pallidus superior frontal gyrus primary visual cortex Top expressed in barrel cortex substantia nigra superior cervical ganglion Region I of hippocampus proper trigeminal ganglion fossa condyle motor neuron medial geniculate nucleus medial dorsal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding RNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific double-stranded DNA binding purine-rich negative regulatory element binding sequence-specific DNA binding Cellular component nucleus Biological process negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29942 75029 Ensembl ENSG00000172733 ENSMUSG00000049184 UniProt Q9UJV8 Q8R4E6 RefSeq (mRNA) NM_001015508 NM_013357 NM_001323311 NM_001323312 NM_001098233 NM_152821 NM_001382855 RefSeq (protein) NP_001015508 NP_001310240 NP_001310241 NP_037489 NP_001091703 NP_690034 NP_001369784 Location (UCSC) Chr 8: 31 – 31.03 Mb Chr 8: 33.88 – 33.91 Mb PubMed search
Wikidata
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Purine-rich element binding protein G is a protein that in humans is encoded by the PURG gene.

Function

The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A (PURA). The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. Two transcript variants encoding different isoforms have been found for this gene.

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.