Parietin
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| Names | |
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| IUPAC name
1,8-dihydroxy-6-methoxy-3-methyl-anthracene-9,10-dione
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| Systematic IUPAC name
1,8-dihydroxy-3-methoxy-6-methylanthraquinone | |
| Other names
Physcion(e), rheochrysidin, methoxyemodin
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| ECHA InfoCard | 100.007.561 |
| KEGG | |
PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C16H12O5 | |
| Molar mass | 284.26348 g/mol |
| Appearance | Orange/yellow |
| Related compounds | |
Related compounds
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Emodin |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Parietin is the predominant cortical pigment of lichens in the genus Caloplaca, a secondary product of the lichen Xanthoria parietina, and a pigment found in the roots of Curled Dock (Rumex crispus). It has an orangy-yellow color and absorbs blue light.
It is also known as physcion.
It has also been shown to protect lichens against UV-B light, at high altitudes in Alpine regions. The UV-B light stimulates production of parietin and the parietin protects the lichens from damage. Lichens in arctic regions such as Svarlbard retain this capability though they do not encounter damaging levels of UV-B, a capability that could be help protect the lichens in case of Ozone layer thinning.[1][2][3]
It has also shown anti-fungal activity against barley powdery mildew and cucumber powdery mildew, more efficiently in the latter case than treatments with fenarimol and polyoxin B.[4]
It reacts with KOH to form a deep, reddish-magenta compound.
Effect on human cancer cells
Also found in rhubarb,[5] the orange compound appears to have potential to suppress 6-phosphogluconate dehydrogenase, or 6PGD. 6PGD is the third enzyme of the pentose phosphate pathway, or PPP, an oxidative process fueling growth in a still-relatively-unknown way. But it appears that arresting the chemical machinery at its third step could be promising for oncology. The parietin, identified from an FDA database of 2,000 known suppressors of 6PGD, killed half the human leukemia cells over two days in the laboratory. The pigment also slowed the growth of other human cancer cells in mouse models, according to the study. A more-potent derivative of the parietin called S3 may even cut the growth of lung cancer cells implanted in mice by two-thirds, over the course of 11 days. The compound also appears to be non-toxic to healthy cells.[6][7]
References
- ^ "Xanthoria parietina is a widespread lichen coloured by the orange cortical pigment parietin (= physcion). We studied the pigment content in 60 thalli sampled in 4 habitats along a sun–shade gradient from evergreen boreal forests through open deciduous stands to sea cliffs. The significant positive regression between contents of parietin per unit area and site factors (reflecting the openness of the canopy relative to an open sky) across sampled habitats suggested a photoprotective role of parietin at UV-B and/or blue wavelengths, the two absorbance maxima of parietin. UV-B susceptibility of X. parietina, measured as permanent reductions in photosystem II, decreased highly significantly with increasing parietin content per thallus area. However, as much as three-fold greater UV-B irradiances than ambient daily summer maxima, maintained continuously for 240 h were required to cause UV-B damage even in thalli of shaded habitats. Since a previous study has documented a high PAR susceptibility of parietin-deficient X. parietina in the absence of UV-B, there are reasons to believe that the blue light screening of parietin is functionally more important than the UV-B screening. A strong positive relationship between parietin content per unit area and reflectance at 500 nm allows the parietin content in X. parietina thalli to be assessed non-destructively by reflectance measurements" [Is parietin a UV-B or a blue-light screening pigment in the lichen Xanthoria parietina?]Yngvar Gauslaa and Elin Margrete Ustvedt, Photochem. Photobiol. Sci., 2003, 2, 424–432
- ^ "This study reports UV screening pigments in the upper cortices of two widespread lichens collected in three sun-exposed locations along a latitudinal gradient from the Arctic lowland to alpine sites of the Central European Alps. Populations from the Alps receive 3–5 times higher UV-B irradiance than their Arctic counterparts from Svalbard because of latitudinal and altitudinal gradients in UV-B irradiance.... This implies that Arctic populations maintain a high level of screening pigments in spite of low ambient UV-B, and that the studied lichen species presumably may tolerate an increase in UV-B radiation due to the predicted thinning of the ozone layer over polar areas" The lichens Xanthoria elegans and Cetraria islandica maintain a high protection against UV-B radiation in Arctic habitats Line Nybakken, Knut Asbjørn Solhaug, Wolfgang Bilger, Yngvar Gauslaa, Oecologia July 2004, Volume 140, Issue 2, pp 211-216
- ^ UV-induction of sun-screening pigments in lichens Knut Asbjørn Solhaug, Yngvar Gauslaa, Line Nybakken and Wolfgang Bilger, New Phytologist Volume 158, Issue 1, pages 91–100, April 2003 doi:10.1046/j.1469-8137.2003.00708.x
- ^ "Effects of chrysophanol, parietin, and nepodin of Rumex crispus on barley and cucumber powdery mildews". Crop Protection. 23 (12): 1215–1221. December 2004. doi:10.1016/j.cropro.2004.05.005.
{{cite journal}}: Unknown parameter|authors=ignored (help) - ^ "Cancer Growth Could be Slowed by Little-known Pigment in Rhubarb". Laboratory Equipment. Retrieved 2015-10-24.
- ^ "Orange lichens are source for potential anticancer drug". news.emory.edu. 2015-10-21. Retrieved 2015-10-24.
- ^ Basile, Adriana; Rigano, Daniela; Loppi, Stefano; Di Santi, Annalisa; Nebbioso, Angela; Sorbo, Sergio; Conte, Barbara; Paoli, Luca; De Ruberto, Francesca (2015-04-09). "Antiproliferative, Antibacterial and Antifungal Activity of the Lichen Xanthoria parietina and Its Secondary Metabolite Parietin". International Journal of Molecular Sciences. 16 (4): 7861–7875. doi:10.3390/ijms16047861. ISSN 1422-0067. PMC 4425054. PMID 25860944.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
- Caloplaca coralloides chemistry
- Edwards, Howell G. M.; Emma M. Newton; David D. Wynn-Williams; Steven R. Coombes (2003-03-12). "Molecular spectroscopic studies of lichen substances 1: parietin and emodin". Journal of Molecular Structure. 648 (1–2): 49–59. Bibcode:2003JMoSt.648...49E. doi:10.1016/S0022-2860(02)00384-8.
- Solhaug, Knut A.; Yngvar Gauslaa (November 1996). "Parietin, a photoprotective secondary product of the lichen Xanthoria parietina". Oecologia. 108 (3): 412–418. doi:10.1007/BF00333715.