Pemberton's sign is the development of facial flushing, distended neck and head superficial veins, inspiratory stridor and elevation of the jugular venous pressure (JVP) upon raising both of the patient's arms above his/her head simultaneously, as high as possible (Pemberton's maneuver).
A positive Pemberton's sign is a sign of superior vena cava syndrome, possibly from a mass in the mediastinum, such as a tumor(for exp.superior lobe of lung cancer) or goiter (thoracic inlet obstruction due to retrosternal goiter or mass).
Apical lung cancers often cause a positive Pemberton's sign and a high index of suspicion should be maintained in patients with symptoms of dyspnea and facial plethora with an extensive smoking history.
- "luc.edu". Retrieved 2008-12-20.
- synd/3558 at Who Named It?
- Pemberton HS. Sign of submerged goitre. Lancet 1946;251:509.
- O'Brien KE, Gopal V, Mazzaferri E (April 2003). "Pemberton's sign associated with a large multinodular goiter". Thyroid 13 (4): 407–8. doi:10.1089/105072503321669929. ISSN 1050-7256. PMID 12804111.
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