3D model (Jmol)
|Molar mass||1097.33 g/mol|
|Appearance||Amorphous, golden-yellow solid|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Perimycin (also known as aminomycin and fungimycin) is polyene antibiotic produced by Streptomyces coelicolor var. aminophilus. The compound exhibits antifungal properties.
Perimycin is produced naturally as a mixture of three types: A, B and C, with type A being the major component. All types consist of a polyketide core with a perosamine sugar moiety. The variations occur at the end of the core opposite the perosamine moiety. Perimycin A has an aromatic group in this position, whereas the identities of the analogous groups in the other perimycin types are currently undetermined.
Polyene antibiotics in general are often toxic to humans and have poor bioavailability. Thus, with the notable exception of amphotericin B, they are often not used clinically. Perimycin has been shown to be an effective antifungal compound, but is not widely used in clinical settings.
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- Elmer, Y. Tu; Charlotte E. Joslina; Lisa M. Nijmc; Robert S. Federd; Sandeep Jaina; Megan E. Shoffe (July 2009). "Polymicrobial Keratitis: Acanthamoeba and Infectious Crystalline Keratopathy". American Journal of Ophthalmology. 148 (1): 13–19.e2. doi:10.1016/j.ajo.2009.01.020. Retrieved 28 January 2010.
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