Piwi like rna-mediated gene silencing 4

PIWIL4
Identifiers
Aliases	PIWIL4, HIWI2, MIWI2, piwi like RNA-mediated gene silencing 4
External IDs	OMIM: 610315; MGI: 3041167; HomoloGene: 45122; GeneCards: PIWIL4; OMA:PIWIL4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	94,621,421 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	14,652,036 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; bone marrow; ; body of pancreas; ; bone marrow cells; ; trabecular bone; ; tibia; ; Achilles tendon; ; mucosa of transverse colon; ; ascending aorta;
	Top expressed in
	pineal gland; ; blastocyst; ; Gonadal ridge; ; Paneth cell; ; left lung lobe; ; embryo; ; cumulus cell; ; embryo; ; tail of embryo; ; lumbar subsegment of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	piRNA binding; RNA binding; nucleic acid binding; endoribonuclease activity;
Cellular component	cytoplasm; piP-body; nucleus; P granule;
Biological process	multicellular organism development; cell differentiation; meiosis; regulation of translation; DNA methylation involved in gamete generation; spermatogenesis; gene silencing; piRNA metabolic process; negative regulation of transposition; RNA phosphodiester bond hydrolysis, endonucleolytic; epithelial structure maintenance;
	Sources:Amigo / QuickGO
Orthologs
	143689
	330890
	ENSG00000134627
	ENSMUSG00000036912
	Q7Z3Z4
	Q8CGT6
	NM_152431
	NM_177905; NM_001368831; NM_001368832; NM_001368836
	NP_689644
	NP_001355760; NP_001355761; NP_001355765
	Wikidata
View/Edit Human	View/Edit Mouse

Piwi like RNA-mediated gene silencing 4 is a protein that in humans is encoded by the PIWIL4 gene. ^[5]

Function

PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134627 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036912 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Piwi like RNA-mediated gene silencing 4". Retrieved 2017-02-11.

Sugimoto K, Kage H, Aki N, Sano A, Kitagawa H, Nagase T, Yatomi Y, Ohishi N, Takai D (2007). "The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus". Biochem. Biophys. Res. Commun. 359 (3): 497–502. doi:10.1016/j.bbrc.2007.05.136. PMID 17544373.
Li L, Yu C, Gao H, Li Y (2010). "Argonaute proteins: potential biomarkers for human colon cancer". BMC Cancer. 10: 38. doi:10.1186/1471-2407-10-38. PMC 2843668. PMID 20146808.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Kim JS, Choi YY, Jin G, Kang HG, Choi JE, Jeon HS, Lee WK, Kim DS, Kim CH, Kim YJ, Son JW, Jung TH, Park JY (2010). "Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study". Mol. Carcinog. 49 (10): 913–21. doi:10.1002/mc.20672. PMID 20721975.
Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X (2010). "Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population". Hum. Reprod. 25 (12): 2955–61. doi:10.1093/humrep/deq274. PMID 20940137.
Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X (2010). "Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population". Hum. Reprod. 25 (12): 2955–61. doi:10.1093/humrep/deq274. PMID 20940137.
Su C, Ren ZJ, Wang F, Liu M, Li X, Tang H (2012). "PIWIL4 regulates cervical cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53". FEBS Lett. 586 (9): 1356–62. doi:10.1016/j.febslet.2012.03.053. PMID 22483988.
Greither T, Koser F, Kappler M, Bache M, Lautenschläger C, Göbel S, Holzhausen HJ, Wach S, Würl P, Taubert H (2012). "Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients". BMC Cancer. 12: 272. doi:10.1186/1471-2407-12-272. PMC 3472179. PMID 22748119.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Bao J, Zhang Y, Schuster AS, Ortogero N, Nilsson EE, Skinner MK, Yan W (2014). "Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice". Cell Death Differ. 21 (5): 783–96. doi:10.1038/cdd.2014.5. PMC 3978311. PMID 24464225.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134627 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036912 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Piwi like RNA-mediated gene silencing 4". Retrieved 2017-02-11.

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Function

References

Further reading