Jump to content

Pleckstrin homology domain containing A4

From Wikipedia, the free encyclopedia
PLEKHA4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLEKHA4, PEPP1, pleckstrin homology domain containing A4
External IDsOMIM: 607769; MGI: 1916467; HomoloGene: 10848; GeneCards: PLEKHA4; OMA:PLEKHA4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001161354
NM_020904

NM_148927
NM_001381849

RefSeq (protein)

NP_001154826
NP_065955

n/a

Location (UCSC)Chr 19: 48.84 – 48.87 MbChr 7: 45.18 – 45.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology domain containing A4 is a protein that in humans is encoded by the PLEKHA4 gene. [5]

Function

[edit]

This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms.

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105559Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040428Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Pleckstrin homology domain containing A4". Retrieved 2017-08-24.

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.