Polyamine-modulated factor 1

PMF1
Identifiers
Aliases	PMF1, polyamine modulated factor 1
External IDs	OMIM: 609176; MGI: 1914287; HomoloGene: 5224; GeneCards: PMF1; OMA:PMF1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,240,042 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,317,638 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; apex of heart; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gastrocnemius muscle; ; right auricle; ; ectocervix; ; skin of leg; ; left ventricle; ; granulocyte;
	Top expressed in
	yolk sac; ; embryo; ; embryo; ; ventricular zone; ; tibiofemoral joint; ; blastocyst; ; internal carotid artery; ; lip; ; morula; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; leucine zipper domain binding; protein binding;
Cellular component	chromosome; cytosol; MIS12/MIND type complex; chromosome, centromeric region; nucleus; kinetochore; transcription regulator complex; nucleoplasm; Golgi apparatus; intracellular membrane-bounded organelle; nuclear MIS12/MIND complex;
Biological process	chromosome segregation; cell division; cell cycle; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	11243
	67037
	ENSG00000160783
	ENSMUSG00000028066
	Q6P1K2
	Q9CPV5
	NM_007221; NM_001199653; NM_001199654
	NM_025928; NM_001310605
	NP_001186582; NP_001186583; NP_009152
	NP_001297534; NP_080204
	Wikidata
View/Edit Human	View/Edit Mouse

Polyamine-modulated factor 1 is a protein that in humans is encoded by the PMF1 gene.^[5]^[6]

Template:PBB Summary

Interactions

Polyamine-modulated factor 1 has been shown to interact with MIS12.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160783 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028066 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Y, Devereux W, Stewart TM, Casero RA Jr (Aug 1999). "Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene". J Biol Chem. 274 (31): 22095–101. doi:10.1074/jbc.274.31.22095. PMID 10419538.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: PMF1 polyamine-modulated factor 1".
^ Cheeseman, Iain M; Niessen Sherry; Anderson Scott; Hyndman Francie; Yates John R; Oegema Karen; Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. 18 (18). United States: 2255–68. doi:10.1101/gad.1234104. ISSN 0890-9369. PMC 517519. PMID 15371340. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11). England: 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading