PVPP, Crospovidone, Polyvidone
3D model (JSmol)
|Abbreviations||PVP, PVPP, NVP, PNVP|
|E number||E1201 (additional chemicals)|
|Molar mass||2,500 – 2,500,000 g·mol−1|
|Appearance||white to light yellow, hygroscopic, amorphous powder|
|Melting point||150 to 180 °C (302 to 356 °F; 423 to 453 K) (glass temperature)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
It is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption. The long-term effects of crospovidone or povidone within the lung are unknown.)
PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others.
It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.
PVP is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology and Air Optix contact lens packaging solution (as an ingredient called "copolymer 845").
PVP is also used in many technical applications:
- as an adhesive in glue stick and hot-melt adhesives
- as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process
- as an emulsifier and disintegrant for solution polymerization
- to increase resolution in photoresists for cathode ray tubes (CRT)
- in aqueous metal quenching
- for production of membranes, such as dialysis and water purification filters
- as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating
- as a thickening agent in tooth whitening gels
- as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation
- as an additive to Doro's RNA extraction buffer
- as a liquid-phase dispersion enhancing agent in DOSY NMR 
- as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly
- as a stabilizing agent in all inorganic solar cells
PVP binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.
PVP is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions. PVP is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.
In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.
The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses, and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP component of the solution. A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP. In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.
Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP instead.
PVP is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin). When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.
A 2014 study found fluorescent properties of PVP and its oxidized hydrolyzate.
PVP was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the derivatives of acetylene chemistry. PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.
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