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"Reaction" is the eighth episode of the American animated television series The Spectacular Spider-Man, which is based on the comic book character Spider-Man, created by Stan Lee and Steve Ditko. The episode originally broadcast in the United States on the Kids WB! block for The CW on May 3, 2008, where it was rated TV-Y7-FV. The episode details Dr. Otto Octavius as a laboratory incident caused by the Green Goblin merges special mechanical tentacles to his skin and turns him from a timid and weak scientist into the villain Dr. Octopus. "Reaction" was directed by Jennifer Coyle and was the first episode of the series to be written by Randy Jandt. While writing the teleplay, Jandt was challenged with staying true to the original material of Spider-Man, particularly towards that of Dr. Octopus. "Reaction" received generally positive reviews, with television critics singling out Dr. Octopus' portrayal. Octopus's character design was applauded by both the designers and Coyle; the latter noted that his design allowed her to direct them freely in different manners, and the that the arms in particular were particularly well-done. Peter MacNicol voiced the character and used a voice inspired by that of late actor Laird Cregar. It is available on both the third volume DVD set for the series, as well as the complete season box set.