Protein THEMIS

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THEMIS
Identifiers
Aliases THEMIS, C6orf190, C6orf207, GASP, SPOT, TSEPA, bA325O24.3, bA325O24.4, thymocyte selection associated
External IDs MGI: 2443552 HomoloGene: 72287 GeneCards: THEMIS
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001010923
NM_001164685
NM_001164687
NM_001318531

NM_178666
NM_001305663

RefSeq (protein)

NP_001010923
NP_001158157
NP_001158159
NP_001305460

NP_001292592.1
NP_848781.1
NP_001292592
NP_848781

Location (UCSC) Chr 6: 127.71 – 127.92 Mb Chr 10: 28.67 – 28.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein THEMIS is a protein that in humans is encoded by the THEMIS gene.[3][4][5]

Function[edit]

This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.[6]

The name[edit]

THEMIS is an acronym for thymocyte-expressed-molecule. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since the protein is important in deciding the fate of the T cell during development.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR (August 2009). "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nat. Immunol. 10 (8): 848–56. doi:10.1038/ni.1766. PMC 2757056Freely accessible. PMID 19597499. 
  4. ^ Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE (August 2009). "Themis, a T cell-specific protein important for late thymocyte development". Nat. Immunol. 10 (8): 840–7. doi:10.1038/ni.1768. PMC 2848698Freely accessible. PMID 19597498. 
  5. ^ Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ, Schwartz RH (August 2009). "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection". Nat. Immunol. 10 (8): 831–9. doi:10.1038/ni.1769. PMC 2908989Freely accessible. PMID 19597497. 
  6. ^ "Entrez Gene: thymocyte selection associated". 
  7. ^ Zielinska E (2009-11-01). "Six degrees of science". The Scientist. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.