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IUPAC name
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3D model (JSmol)
ECHA InfoCard 100.122.141
Molar mass 256.301 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Pterostilbene[p] is a stilbenoid chemically related to resveratrol. In plants, it serves a defensive phytoalexin role.[1]

Natural occurrence[edit]

Pterostilbene is found in almonds,[2] various Vaccinium berries,[3] grape leaves and vines [1][4] and blueberries.[5][6]

Regulation, safety and research[edit]

As pterostilbene is absent on the list of compounds with GRAS by the US Food and Drug Administration (FDA), its safety for consumption remains unproven as of 2019.[7] Its chemical relative, resveratrol, did receive FDA GRAS status in 2007,[8] and approval of synthetic resveratrol as a safe compound by the European Food Safety Authority (EFSA) in 2016.[9] The EFSA Scientific Panel concluded that "at daily doses up to 150 mg per day, resveratrol does not have a nutritionally relevant role in the human diet".[9] As of 2019, there are no published studies of clinical research on the safety or efficacy of pterostilbene.

See also[edit]

  • Piceatannol, a stilbenoid related to both resveratrol and pterostilbene


[p] ^ The term "pterostilbene" is pronounced /teh-ro-Still-bean/.[10][11]


  1. ^ a b Langcake, P.; Pryce, R. J. (1977). "A new class of phytoalexins from grapevines". Experientia. 33 (2): 151–2. doi:10.1007/BF02124034. PMID 844529.
  2. ^ Xie L, Bolling BW (2014). "Characterisation of stilbenes in California almonds (Prunus dulcis) by UHPLC-MS". Food Chem. 148 (Apr 1): 300–6. doi:10.1016/j.foodchem.2013.10.057. PMID 24262561.
  3. ^ Rimando AM, Kalt W, Magee JB, Dewey J, Ballington JR (2004). "Resveratrol, pterostilbene, and piceatannol in vaccinium berries". J Agric Food Chem. 52 (15): 4713–9. doi:10.1021/jf040095e. PMID 15264904.
  4. ^ Becker L, Carré V, Poutaraud A, Merdinoglu D, Chaimbault P (2014). "MALDI mass spectrometry imaging for the simultaneous location of resveratrol, pterostilbene and viniferins on grapevine leaves". Molecules. 19 (7): 10587–600. doi:10.3390/molecules190710587. PMID 25050857.
  5. ^ "USDA ARS Online Magazine Vol. 54, No. 11". Retrieved 2016-03-21.
  6. ^ McCormack, Denise; McFadden, David (2013-01-01). "A Review of Pterostilbene Antioxidant Activity and Disease Modification". Oxidative Medicine and Cellular Longevity. 2013: 1–15. doi:10.1155/2013/575482. ISSN 1942-0900. PMC 3649683. PMID 23691264.
  7. ^ "Pterostilbene search". US Food and Drug Administration, Food Ingredient and Packaging Inventories. 6 February 2019. Retrieved 7 February 2019.
  8. ^ "GRAS Notice GRN 224: Resveratrol". US Food and Drug Administration, Food Ingredient and Packaging Inventories. 1 August 2007. Retrieved 7 February 2019.
  9. ^ a b "Safety of synthetic trans‐resveratrol as a novel food pursuant to Regulation (EC) No 258/97". EFSA Journal. European Food Safety Authority, EFSA Panel on Dietetic Products, Nutrition and Allergies. 14 (1). 12 January 2016. doi:10.2903/j.efsa.2016.4368. Retrieved 7 February 2019.
  10. ^ "Pterostigma Medical Definition". June 2018. Retrieved 2018-07-30.
  11. ^ "Stilbene Medical Definition". June 2018. Retrieved 2018-07-30.