Pyridoxine 5'-phosphate synthase

Pyridoxine 5'-phosphate synthase
Identifiers
EC no.	2.6.99.2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a pyridoxine 5'-phosphate synthase (EC 2.6.99.2) is an enzyme that catalyzes the chemical reaction

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate $\rightleftharpoons$ pyridoxine 5'-phosphate + phosphate + 2 H₂O

Thus, the two substrates of this enzyme are 1-deoxy-D-xylulose 5-phosphate and 3-amino-2-oxopropyl phosphate, whereas its 3 products are pyridoxine 5'-phosphate, phosphate, and H₂O.

Classification

This enzyme belongs to the family of transferases, specifically those transferring nitrogenous groups transferring other nitrogenous groups.

Nomenclature

The systematic name of this enzyme class is 1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing). Other names in common use include pyridoxine 5-phosphate phospho lyase, PNP synthase, and PdxJ.

Biological role

This enzyme participates in vitamin B₆ metabolism.

References

• Garrido-Franco M (2003). "Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B₆ and beyond". Biochim. Biophys. Acta. 1647 (1–2): 92–7. doi:10.1016/s1570-9639(03)00065-7. PMID 12686115.
• Garrido-Franco M, Laber B, Huber R, Clausen T (2002). "Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis". J. Mol. Biol. 321 (4): 601–12. doi:10.1016/S0022-2836(02)00695-2. PMID 12206776.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS (1999). "Vitamin B₆ biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein". FEBS Lett. 449 (1): 45–8. doi:10.1016/S0014-5793(99)00393-2. PMID 10225425.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Franco MG, Laber B, Huber R, Clausen T (2001). "Structural basis for the function of pyridoxine 5'-phosphate synthase". Structure. 9 (3): 245–53. doi:10.1016/S0969-2126(01)00584-6. PMID 11286891.{{cite journal}}: CS1 maint: multiple names: authors list (link)