QSOX1

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QSOX1
Protein QSOX1 PDB 3LLI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases QSOX1, Q6, QSCN6, quiescin sulfhydryl oxidase 1
External IDs MGI: 1330818 HomoloGene: 37690 GeneCards: 5768
RNA expression pattern
PBB GE QSCN6 201482 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002826
NM_001004128

NM_001024945
NM_023268

RefSeq (protein)

NP_001004128.1
NP_002817.2

NP_001020116.1
NP_075757.1

Location (UCSC) Chr 1: 180.15 – 180.2 Mb Chr 1: 155.78 – 155.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sulfhydryl oxidase 1 is an enzyme that in humans is encoded by the QSOX1 gene.[3][4][5]

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Coppock DL, Cina-Poppe D, Gilleran S (Feb 1999). "The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1". Genomics. 54 (3): 460–8. doi:10.1006/geno.1998.5605. PMID 9878249. 
  4. ^ Coppock DL, Kopman C, Scandalis S, Gilleran S (Oct 1993). "Preferential gene expression in quiescent human lung fibroblasts". Cell Growth Differ. 4 (6): 483–93. PMID 8396966. 
  5. ^ a b "Entrez Gene: QSCN6 quiescin Q6". 

Further reading[edit]