RAD54B

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RAD54B
Identifiers
Aliases RAD54B, RDH54, RAD54 homolog B (S. cerevisiae)
External IDs MGI: 3605986 HomoloGene: 8240 GeneCards: RAD54B
RNA expression pattern
PBB GE RAD54B 219494 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_134434
NM_001205262
NM_001205263
NM_006550
NM_012415

NM_001039556
NM_001256145
NM_177285

RefSeq (protein)

NP_001192192.1
NP_036547.1
NP_001243070

NP_001243071.1
NP_001243074.1
NP_001243071
NP_001034645.1

Location (UCSC) Chr 8: 94.37 – 94.48 Mb Chr 4: 11.56 – 11.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

DNA repair and recombination protein RAD54B is a protein that in humans is encoded by the RAD54B gene.[3][4][5]

The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer.[5]

Interactions[edit]

RAD54B has been shown to interact with RAD51.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hiramoto T, Nakanishi T, Sumiyoshi T, Fukuda T, Matsuura S, Tauchi H, Komatsu K, Shibasaki Y, Inui H, Watatani M, Yasutomi M, Sumii K, Kajiyama G, Kamada N, Miyagawa K, Kamiya K (Jun 1999). "Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer". Oncogene. 18 (22): 3422–6. doi:10.1038/sj.onc.1202691. PMID 10362364. 
  4. ^ a b Tanaka K, Hiramoto T, Fukuda T, Miyagawa K (Sep 2000). "A novel human rad54 homologue, Rad54B, associates with Rad51". J Biol Chem. 275 (34): 26316–21. doi:10.1074/jbc.M910306199. PMID 10851248. 
  5. ^ a b "Entrez Gene: RAD54B RAD54 homolog B (S. cerevisiae)". 

Further reading[edit]