RASGRP2

RASGRP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MA2
Identifiers
Aliases	RASGRP2, CALDAG-GEFI, CDC25L, RAS guanyl releasing protein 2
External IDs	OMIM: 605577; MGI: 1333849; HomoloGene: 4250; GeneCards: RASGRP2; OMA:RASGRP2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,745,456 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; monocyte; ; apex of heart; ; right coronary artery; ; popliteal artery; ; blood; ; tibial arteries; ; lymph node; ; left coronary artery;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; diacylglycerol binding; lipid binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; cell projection; membrane; plasma membrane; synapse; ruffle membrane; cell junction; neuron projection;
Biological process	cellular response to calcium ion; intracellular signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity; regulation of cell growth; Ras protein signal transduction; signal transduction; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	10235
	19395
	ENSG00000068831
	ENSMUSG00000032946
	Q7LDG7
	Q9QUG9
	NM_001098670; NM_001098671; NM_005825; NM_153819; NM_001318398
	NM_011242
	NP_001092140; NP_001092141; NP_001305327; NP_722541
	NP_035372; NP_001351991; NP_001351992
	Wikidata
View/Edit Human	View/Edit Mouse

RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.^[4]^[5]

Clinical significance

Mutations in RASGRP2 are associated with Template:SWL.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000068831 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM (Nov 1998). "A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia". Proc Natl Acad Sci U S A. 95 (22): 13278–83. doi:10.1073/pnas.95.22.13278. PMC 23782. PMID 9789079.
^ "Entrez Gene: RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)".
^ Canault, M; Ghalloussi, D; Grosdidier, C; Guinier, M; Perret, C; Chelghoum, N; Germain, M; Raslova, H; Peiretti, F; Morange, P. E.; Saut, N; Pillois, X; Nurden, A. T.; Cambien, F; Pierres, A; Van Den Berg, T. K.; Kuijpers, T. W.; Alessi, M. C.; Tregouet, D. A. (2014). "Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding". Journal of Experimental Medicine. 211: 1349–62. doi:10.1084/jem.20130477. PMID 24958846.

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