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Available structures
PDB Ortholog search: PDBe RCSB
Aliases RBBP9, BOG, RBBP10, retinoblastoma binding protein 9, RB binding protein 9, serine hydrolase
External IDs MGI: 1347074 HomoloGene: 4816 GeneCards: RBBP9
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 20: 18.49 – 18.5 Mb Chr 2: 144.54 – 144.55 Mb
PubMed search [1] [2]
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Putative hydrolase RBBP9 is an enzyme that in humans is encoded by the RBBP9 gene.[3][4][5]


The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate.[5]


RBBP9 has been shown to interact with Retinoblastoma protein.[3]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics. 19 (4): 371–4. doi:10.1038/1258. PMID 9697699. 
  4. ^ Woitach JT, Hong R, Keck CL, Zimonjic DB, Popescu NC, Thorgeirsson SS (Oct 1999). "Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 85 (3-4): 252–3. doi:10.1159/000015304. PMID 10449909. 
  5. ^ a b "Entrez Gene: RBBP9 retinoblastoma binding protein 9". 

Further reading[edit]

  • Chen JZ, Yang QS, Wang S, Meng XF, Ying K, Xie Y, Ma YM (Aug 2002). "Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10". Biochemical Genetics. 40 (7-8): 273–82. doi:10.1023/A:1019886918029. PMID 12296629. 
  • Chen J, Ji C, Gu S, Zhao E, Dai J, Huang L, Qian J, Ying K, Xie Y, Mao Y (2003). "Isolation and identification of a novel cDNA that encodes human yrdC protein". Journal of Human Genetics. 48 (4): 164–9. doi:10.1007/s10038-002-0001-3. PMID 12730717. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.