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RBBP9

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RBBP9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRBBP9, BOG, RBBP10, retinoblastoma binding protein 9, RB binding protein 9, serine hydrolase
External IDsOMIM: 602908; MGI: 1347074; HomoloGene: 4816; GeneCards: RBBP9; OMA:RBBP9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006606
NM_153328

NM_015754

RefSeq (protein)

NP_006597

NP_056569

Location (UCSC)Chr 20: 18.49 – 18.5 MbChr 2: 144.38 – 144.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Putative hydrolase RBBP9 is an enzyme that in humans is encoded by the RBBP9 gene.[5][6][7]

Function

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The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate.[7]

Interactions

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RBBP9 has been shown to interact with Retinoblastoma protein.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089050Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027428Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics. 19 (4): 371–4. doi:10.1038/1258. PMID 9697699. S2CID 11374970.
  6. ^ Woitach JT, Hong R, Keck CL, Zimonjic DB, Popescu NC, Thorgeirsson SS (Oct 1999). "Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 252–3. doi:10.1159/000015304. PMID 10449909. S2CID 21843409.
  7. ^ a b "Entrez Gene: RBBP9 retinoblastoma binding protein 9".

Further reading

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