RBM8A

RBM8A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P27, 2HYI, 2J0Q, 2J0S, 2XB2, 3EX7
Identifiers
Aliases	RBM8A, BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1, RNA binding motif protein 8A
External IDs	OMIM: 605313; MGI: 1913129; HomoloGene: 3744; GeneCards: RBM8A; OMA:RBM8A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	145,927,678 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,541,107 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; Achilles tendon; ; olfactory zone of nasal mucosa; ; gastrocnemius muscle; ; islet of Langerhans; ; skin of abdomen; ; monocyte; ; right testis; ; left testis;
	Top expressed in
	embryo; ; embryo; ; interventricular septum; ; ventricular zone; ; blastocyst; ; yolk sac; ; morula; ; dentate gyrus of hippocampal formation granule cell; ; epiblast; ; neural layer of retina;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding; mRNA binding;
Cellular component	cytosol; catalytic step 2 spliceosome; exon-exon junction complex; soma; dendrite; spliceosomal complex; nucleus; cytoplasm; nucleoplasm; nuclear speck; U2-type catalytic step 1 spliceosome;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA transport; RNA processing; mRNA processing; regulation of alternative mRNA splicing, via spliceosome; mRNA export from nucleus; mRNA 3'-end processing; regulation of translation; RNA export from nucleus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA splicing; transport;
	Sources:Amigo / QuickGO
Orthologs
	9939
	60365
	ENSG00000265241
	ENSMUSG00000038374
	Q9Y5S9
	Q9CWZ3
	NM_005105
	NM_001102407; NM_025875
	NP_005096
	NP_001095877; NP_080151
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein 8A is a protein that in humans is encoded by the RBM8A gene.^[5]^[6]

Template:PBB Summary

Interactions

RBM8A has been shown to interact with IPO13,^[7] MAGOH^[8]^[9] and UPF3A.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000265241 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038374 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Conklin DC, Rixon MW, Kuestner RE, Maurer MF, Whitmore TE, Millar RP (October 2000). "Cloning and gene expression of a novel human ribonucleoprotein". Biochim Biophys Acta. 1492 (2–3): 465–9. doi:10.1016/s0167-4781(00)00090-7. PMID 11004516.
^ Salicioni AM, Xi M, Vanderveer LA, Balsara B, Testa JR, Dunbrack RL Jr, Godwin AK (October 2000). "Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor". Genomics. 69 (1): 54–62. doi:10.1006/geno.2000.6315. PMID 11013075.
^ Mingot, J M; Kostka S; Kraft R; Hartmann E; Görlich D (July 2001). "Importin 13: a novel mediator of nuclear import and export". EMBO J. 20 (14). England: 3685–94. doi:10.1093/emboj/20.14.3685. ISSN 0261-4189. PMC 125545. PMID 11447110. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Zhao, X F; Nowak N J; Shows T B; Aplan P D (January 2000). "MAGOH interacts with a novel RNA-binding protein". Genomics. 63 (1). UNITED STATES: 145–8. doi:10.1006/geno.1999.6064. ISSN 0888-7543. PMID 10662555. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Kataoka, N; Diem M D; Kim V N; Yong J; Dreyfuss G (November 2001). "Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon–exon junction complex". EMBO J. 20 (22). England: 6424–33. doi:10.1093/emboj/20.22.6424. ISSN 0261-4189. PMC 125744. PMID 11707413. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Kim, V N; Kataoka N; Dreyfuss G (September 2001). "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex". Science. 293 (5536). United States: 1832–6. doi:10.1126/science.1062829. ISSN 0036-8075. PMID 11546873. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
^ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

RBM8A

Interactions

Related gene problems

References

Further reading