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Protein RCC1 PDB 1a12.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesRCC1, CHC1, RCC1-I, SNHG3-regulator of chromosome condensation 1
External IDsMGI: 1913989 HomoloGene: 55567 GeneCards: RCC1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RCC1
Genomic location for RCC1
Band1p35.3Start28,505,943 bp[1]
End28,539,300 bp[1]
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC)Chr 1: 28.51 – 28.54 MbChr 4: 132.33 – 132.35 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.[5]

RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase.


RCC1 has been shown to interact with RANBP3[6][7] and Ran (biology).[8][9][10][11]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180198 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028896 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: RCC1 Regulator of chromosome condensation 1". 
  6. ^ Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. United States. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. ISSN 0021-9258. PMID 11932251. 
  7. ^ Mueller, L; Cordes V C; Bischoff F R; Ponstingl H (May 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett. NETHERLANDS. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. ISSN 0014-5793. PMID 9637251. 
  8. ^ Steggerda, S M; Paschal B M (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". J. Biol. Chem. UNITED STATES. 275 (30): 23175–80. doi:10.1074/jbc.C000252200. ISSN 0021-9258. PMID 10811801. 
  9. ^ Renault, L; Kuhlmann J; Henkel A; Wittinghofer A (April 2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell. United States. 105 (2): 245–55. doi:10.1016/S0092-8674(01)00315-4. ISSN 0092-8674. PMID 11336674. 
  10. ^ Azuma, Y; Renault L; García-Ranea J A; Valencia A; Nishimoto T; Wittinghofer A (June 1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". J. Mol. Biol. ENGLAND. 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. ISSN 0022-2836. PMID 10369786. 
  11. ^ Ren, M; Villamarin A; Shih A; Coutavas E; Moore M S; LoCurcio M; Clarke V; Oppenheim J D; D'Eustachio P; Rush M G (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Mol. Cell. Biol. UNITED STATES. 15 (4): 2117–24. ISSN 0270-7306. PMC 230439Freely accessible. PMID 7891706. 

Further reading[edit]