RCC1

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RCC1
Protein RCC1 PDB 1a12.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RCC1, CHC1, RCC1-I, SNHG3-regulator of chromosome condensation 1
External IDs MGI: 1913989 HomoloGene: 55567 GeneCards: RCC1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001048194
NM_001048195
NM_001048199
NM_001269

NM_001197082
NM_133878

RefSeq (protein)

NP_598639.1
NP_001184011
NP_598639

Location (UCSC) Chr 1: 28.51 – 28.54 Mb Chr 4: 132.33 – 132.35 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.[3]

RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase.

Interactions[edit]

RCC1 has been shown to interact with RANBP3[4][5] and Ran (biology).[6][7][8][9]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: RCC1 Regulator of chromosome condensation 1". 
  4. ^ Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. United States. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. ISSN 0021-9258. PMID 11932251. 
  5. ^ Mueller, L; Cordes V C; Bischoff F R; Ponstingl H (May 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett. NETHERLANDS. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. ISSN 0014-5793. PMID 9637251. 
  6. ^ Steggerda, S M; Paschal B M (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". J. Biol. Chem. UNITED STATES. 275 (30): 23175–80. doi:10.1074/jbc.C000252200. ISSN 0021-9258. PMID 10811801. 
  7. ^ Renault, L; Kuhlmann J; Henkel A; Wittinghofer A (April 2001). "Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1)". Cell. United States. 105 (2): 245–55. doi:10.1016/S0092-8674(01)00315-4. ISSN 0092-8674. PMID 11336674. 
  8. ^ Azuma, Y; Renault L; García-Ranea J A; Valencia A; Nishimoto T; Wittinghofer A (June 1999). "Model of the ran-RCC1 interaction using biochemical and docking experiments". J. Mol. Biol. ENGLAND. 289 (4): 1119–30. doi:10.1006/jmbi.1999.2820. ISSN 0022-2836. PMID 10369786. 
  9. ^ Ren, M; Villamarin A; Shih A; Coutavas E; Moore M S; LoCurcio M; Clarke V; Oppenheim J D; D'Eustachio P; Rush M G (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Mol. Cell. Biol. UNITED STATES. 15 (4): 2117–24. ISSN 0270-7306. PMC 230439Freely accessible. PMID 7891706. 

Further reading[edit]