Reticulocalbin 1

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RCN1
Identifiers
Aliases RCN1, HEL-S-84, PIG20, RCAL, RCN, reticulocalbin 1
External IDs MGI: 104559 HomoloGene: 20637 GeneCards: RCN1
RNA expression pattern
PBB GE RCN1 201063 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002901

NM_009037

RefSeq (protein)

NP_002892

NP_033063.1
NP_033063

Location (UCSC) Chr 11: 31.81 – 32.11 Mb Chr 2: 105.39 – 105.4 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Reticulocalbin-1 is a protein that in humans is encoded by the RCN1 gene.[3][4][5]

Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kent J, Lee M, Schedl A, Boyle S, Fantes J, Powell M, Rushmere N, Abbott C, van Heyningen V, Bickmore WA (Sep 1997). "The reticulocalbin gene maps to the WAGR region in human and to the Small eye Harwell deletion in mouse". Genomics. 42 (2): 260–7. doi:10.1006/geno.1997.4706. PMID 9192846. 
  4. ^ Ozawa M (Mar 1996). "Cloning of a human homologue of mouse reticulocalbin reveals conservation of structural domains in the novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs". J Biochem. 117 (5): 1113–9. PMID 8586628. 
  5. ^ a b "Entrez Gene: RCN1 reticulocalbin 1, EF-hand calcium binding domain". 

Further reading[edit]