RFWD2

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COP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases COP1, RNF200, ring finger and WD repeat domain 2, E3 ubiquitin ligase, RFWD2
External IDs MGI: 1347046 HomoloGene: 115565 GeneCards: COP1
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for COP1
Genomic location for COP1
Band 1q25.1-q25.2 Start 175,944,831 bp[1]
End 176,207,493 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001740
NM_001286644
NM_022457

NM_011931
NM_001360878

RefSeq (protein)

NP_001001740
NP_001273573
NP_071902

NP_036061
NP_001347807

Location (UCSC) Chr 1: 175.94 – 176.21 Mb Chr 1: 159.23 – 159.35 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene.[5][6]

Interactions[edit]

RFWD2 has been shown to interact with C-jun.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143207 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040782 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Wang H, Kang D, Deng XW, Wei N (Sep 1999). "Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1". Curr Biol. 9 (13): 711–4. doi:10.1016/S0960-9822(99)80314-5. PMID 10395541. 
  6. ^ "Entrez Gene: RFWD2 ring finger and WD repeat domain 2". 
  7. ^ Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM (Feb 2004). "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase". Science. 303 (5662): 1371–4. doi:10.1126/science.1093549. PMID 14739464. 
  8. ^ Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, Putignano S, Rogge L, Pardi R (May 2003). "Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity". J. Biol. Chem. 278 (22): 19682–90. doi:10.1074/jbc.M212681200. PMID 12615916. 

Further reading[edit]