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AliasesRGS13, regulator of G protein signaling 13
External IDsMGI: 2180585 HomoloGene: 14774 GeneCards: RGS13
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RGS13
Genomic location for RGS13
Band1q31.2Start192,636,138 bp[1]
End192,660,306 bp[1]
RNA expression pattern
PBB GE RGS13 210258 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 192.64 – 192.66 MbChr 1: 144.14 – 144.18 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Regulator of G-protein signaling 13 is a protein that in humans is encoded by the RGS13 gene.[5][6]

RGS 13 is a member of R4 subfamily of RGS (Regulators of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.[7]

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127074 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051079 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem. 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076.
  6. ^ a b "Entrez Gene: RGS13 regulator of G-protein signalling 13".
  7. ^ Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105.

Further reading[edit]