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Regulator of G-protein signaling 19
Protein RGS19 PDB 1cmz.png
PDB rendering based on 1cmz.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM605071 MGI1915153 HomoloGene23320 GeneCards: RGS19 Gene
RNA expression pattern
PBB GE RGS19 204336 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10287 56470
Ensembl ENSG00000171700 ENSMUSG00000002458
UniProt P49795 Q9CX84
RefSeq (mRNA) NM_001039467 NM_001291205
RefSeq (protein) NP_001034556 NP_001278134
Location (UCSC) Chr 20:
64.07 – 64.08 Mb
Chr 2:
181.69 – 181.69 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.[1][2]

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.[2][3]


RGS19 has been shown to interact with GNAO1,[4][5] GIPC1,[6] OSTM1,[7] GNAI1,[4][5] GNAI3[1][4][5] and GNAZ.[4][8]


  1. ^ a b De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874. 
  2. ^ a b "Entrez Gene: RGS19 regulator of G-protein signalling 19". 
  3. ^ Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726. 
  4. ^ a b c d De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788. 
  5. ^ a b c Woulfe, D S; Stadel J M (June 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. (UNITED STATES) 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213. 
  6. ^ Lou, X; Yano H; Lee F; Chao M V; Farquhar M G (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell (United States) 12 (3): 615–27. doi:10.1091/mbc.12.3.615. ISSN 1059-1524. PMC 30968. PMID 11251075. 
  7. ^ Fischer, Thierry; De Vries Luc; Meerloo Timo; Farquhar Marilyn Gist (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (14): 8270–5. doi:10.1073/pnas.1432965100. ISSN 0027-8424. PMC 166218. PMID 12826607. 
  8. ^ Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. (UNITED STATES) 275 (41): 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137. 

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