RGS19

RGS19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CMZ
Identifiers
Aliases	RGS19, GAIP, RGSGAIP, regulator of G-protein signaling 19, regulator of G protein signaling 19
External IDs	OMIM: 605071; MGI: 1915153; HomoloGene: 23320; GeneCards: RGS19; OMA:RGS19 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	64,079,988 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	181,335,770 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; monocyte; ; spleen; ; bone marrow cells; ; parotid gland; ; trabecular bone; ; lymph node; ; amniotic fluid; ; appendix;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; external carotid artery; ; spleen; ; blood; ; thymus; ; internal carotid artery; ; yolk sac; ; condyle; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; protein binding; G-protein alpha-subunit binding; GTPase activity;
Cellular component	cytoplasm; Golgi apparatus; membrane; brush border; heterotrimeric G-protein complex; membrane raft; clathrin-coated vesicle; cytoplasmic vesicle; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; small GTPase mediated signal transduction; autophagy; negative regulation of signal transduction; positive regulation of GTPase activity; response to ethanol;
	Sources:Amigo / QuickGO
Orthologs
	10287
	56470
	ENSG00000171700
	ENSMUSG00000002458
	P49795
	Q9CX84
	NM_001039467; NM_005873
NM_001291205; NM_001291206; NM_001291207; NM_001291208; NM_001291209;
	NM_001291210; NM_026446
	NP_001034556; NP_005864
NP_001278134; NP_001278135; NP_001278136; NP_001278137; NP_001278138;
	NP_001278139; NP_080722
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.^[5]^[6]

Template:PBB Summary

Interactions

RGS19 has been shown to interact with GNAO1,^[7]^[8] GIPC1,^[9] OSTM1,^[10] GNAI1,^[7]^[8] GNAI3^[5]^[7]^[8] and GNAZ.^[7]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171700 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002458 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.
^ "Entrez Gene: RGS19 regulator of G-protein signalling 19".
^ ^a ^b ^c ^d De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26). UNITED STATES: 15203–8. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ ^a ^b ^c Woulfe, D S; Stadel J M (June 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. 274 (25). UNITED STATES: 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ Lou, X; Yano H; Lee F; Chao M V; Farquhar M G (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell. 12 (3). United States: 615–27. doi:10.1091/mbc.12.3.615. ISSN 1059-1524. PMC 30968. PMID 11251075. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Fischer, Thierry; De Vries Luc; Meerloo Timo; Farquhar Marilyn Gist (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. 100 (14). United States: 8270–5. doi:10.1073/pnas.1432965100. ISSN 0027-8424. PMC 166218. PMID 12826607. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41). UNITED STATES: 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

External links

RGS19 human gene location in the UCSC Genome Browser.
RGS19 human gene details in the UCSC Genome Browser.

Template:PBB Controls

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171700 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002458 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8524874-5] De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.

[entrez-6] "Entrez Gene: RGS19 regulator of G-protein signalling 19".

[pmid8986788-7] De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. 93 (26). UNITED STATES: 15203–8. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[pmid10364213-8] Woulfe, D S; Stadel J M (June 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. 274 (25). UNITED STATES: 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

[pmid11251075-9] Lou, X; Yano H; Lee F; Chao M V; Farquhar M G (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell. 12 (3). United States: 615–27. doi:10.1091/mbc.12.3.615. ISSN 1059-1524. PMC 30968. PMID 11251075. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[pmid12826607-10] Fischer, Thierry; De Vries Luc; Meerloo Timo; Farquhar Marilyn Gist (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. 100 (14). United States: 8270–5. doi:10.1073/pnas.1432965100. ISSN 0027-8424. PMC 166218. PMID 12826607. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[pmid10906137-11] Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41). UNITED STATES: 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

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Interactions

References

Further reading

External links