RGS8

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RGS8
Protein RGS8 PDB 2ihd.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRGS8, regulator of G protein signaling 8
External IDsMGI: 108408 HomoloGene: 23152 GeneCards: RGS8
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RGS8
Genomic location for RGS8
Band1q25.3Start182,641,816 bp[1]
End182,684,576 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001102450
NM_033345

NM_026380
NM_001347115
NM_001357525

RefSeq (protein)

NP_001095920
NP_203131

NP_001334044
NP_080656
NP_001344454

Location (UCSC)Chr 1: 182.64 – 182.68 MbChr 1: 153.65 – 153.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.[5][6]


This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135824 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042671 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
  6. ^ a b "Entrez Gene: RGS8 regulator of G-protein signalling 8".

Further reading[edit]