RIPK4

RIPK4
Identifiers
Aliases	RIPK4, ANKK2, ANKRD3, DIK, NKRD3, PKK, PPS2, RIP4, receptor interacting serine/threonine kinase 4, CHANDS
External IDs	OMIM: 605706; MGI: 1919638; HomoloGene: 10772; GeneCards: RIPK4; OMA:RIPK4 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	41,767,089 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	97,564,987 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; palpebral conjunctiva; ; oral cavity; ; amniotic fluid; ; epithelium of bronchus; ; mucosa of paranasal sinus; ; nasal epithelium; ; bronchial epithelial cell; ; mucosa of pharynx; ; kidney tubule;
	Top expressed in
	transitional epithelium of urinary bladder; ; conjunctival fornix; ; hair follicle; ; seminal vesicula; ; skin of external ear; ; skin of abdomen; ; skin of back; ; epithelium of small intestine; ; cornea; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase activity; ATP binding; kinase activity; nucleotide binding; protein kinase activity; transferase activity; protein binding;
Cellular component	membrane; cytoplasm;
Biological process	protein phosphorylation; morphogenesis of an epithelium; positive regulation of NF-kappaB transcription factor activity; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	54101
	72388
	ENSG00000183421
	ENSMUSG00000005251
	P57078
	Q9ERK0
	NM_020639
	NM_023663
	n/a
	NP_076152
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4 gene.^[5]^[6]

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.^[6]

Interactions

RIPK4 has been shown to interact with PRKCB1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183421 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005251 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (June 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
^ ^a ^b "Entrez Gene: RIPK4 receptor-interacting serine-threonine kinase 4".
^ Chen, L; Haider K; Ponda M; Cariappa A; Rowitch D; Pillai S (June 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. ISSN 0021-9258. PMID 11278382.

External links

RIPK4 human gene location in the UCSC Genome Browser.
RIPK4 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183421 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005251 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10830953-5] Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (June 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.

[entrez-6] "Entrez Gene: RIPK4 receptor-interacting serine-threonine kinase 4".

[pmid11278382-7] Chen, L; Haider K; Ponda M; Cariappa A; Rowitch D; Pillai S (June 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. ISSN 0021-9258. PMID 11278382.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Interactions

References

Further reading

External links