RLF (gene)

RLF
Identifiers
Aliases	RLF, ZN-15L, ZNF292L, rearranged L-myc fusion, RLF zinc finger
External IDs	OMIM: 180610; MGI: 1924705; HomoloGene: 8243; GeneCards: RLF; OMA:RLF - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	40,240,921 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	121,072,281 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; cartilage tissue; ; Achilles tendon; ; ventricular zone; ; sperm; ; endothelial cell; ; testicle; ; embryo; ; ganglionic eminence; ; middle temporal gyrus;
	Top expressed in
	saccule; ; Rostral migratory stream; ; otic placode; ; granulocyte; ; otic vesicle; ; Gonadal ridge; ; tail of embryo; ; genital tubercle; ; lumbar spinal ganglion; ; hand;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; zinc ion binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; DNA integration; chromosome organization; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of DNA methylation; histone H3-K4 monomethylation;
	Sources:Amigo / QuickGO
Orthologs
	6018
	109263
	ENSG00000117000
	ENSMUSG00000049878
	Q13129
	n/a
	NM_012421
	NM_001081013; NM_001346660
	NP_036553
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein Rlf is a protein that in humans is encoded by the RLF gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117000 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049878 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Makela TP, Kere J, Winqvist R, Alitalo K (Aug 1991). "Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer". Mol Cell Biol. 11 (8): 4015–21. doi:10.1128/mcb.11.8.4015. PMC 361204. PMID 1649386.
^ "Entrez Gene: RLF rearranged L-myc fusion".

Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Gregory SG; Barlow KF; McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Swick L, Kapatos G (2006). "A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions". J. Neurochem. 97 (5): 1447–55. doi:10.1111/j.1471-4159.2006.03836.x. PMC 2239266. PMID 16696853.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F; Jacq X; Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Lanigan TM; Liu A; Huang YZ; et al. (2003). "Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf". FASEB J. 17 (14): 2048–60. doi:10.1096/fj.02-1096com. hdl:2027.42/154294. PMID 14597674. S2CID 22523818.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shao H, Kadono-Okuda K, Finlin BS, Andres DA (1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Arch. Biochem. Biophys. 371 (2): 207–19. doi:10.1006/abbi.1999.1448. PMID 10545207.
Mäkelä TP; Hellsten E; Vesa J; et al. (1996). "The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein". Oncogene. 11 (12): 2699–704. PMID 8545128.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117000 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049878 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1649386-5] Makela TP, Kere J, Winqvist R, Alitalo K (Aug 1991). "Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer". Mol Cell Biol. 11 (8): 4015–21. doi:10.1128/mcb.11.8.4015. PMC 361204. PMID 1649386.

[entrez-6] "Entrez Gene: RLF rearranged L-myc fusion".

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References

Further reading