RNF20

RNF20
Identifiers
Aliases	RNF20, BRE1, BRE1A, hBRE1, ring finger protein 20
External IDs	OMIM: 607699; MGI: 1925927; HomoloGene: 5571; GeneCards: RNF20; OMA:RNF20 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	101,563,344 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	49,656,887 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; cardiac muscle tissue of right atrium; ; myocardium of left ventricle; ; mucosa of ileum; ; deltoid muscle; ; caput epididymis; ; bronchial epithelial cell; ; parietal pleura; ; retinal pigment epithelium; ; corpus callosum;
	Top expressed in
	tail of embryo; ; genital tubercle; ; blood; ; neural layer of retina; ; seminal vesicula; ; secondary oocyte; ; zygote; ; granulocyte; ; maxillary prominence; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; histone binding; p53 binding; chromatin binding; metal ion binding; mRNA 3'-UTR binding; protein binding; ubiquitin protein ligase binding; transferase activity; ubiquitin-protein transferase activity;
Cellular component	ubiquitin ligase complex; HULC complex; nucleolus; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; negative regulation of mRNA polyadenylation; positive regulation of histone methylation; ubiquitin-dependent protein catabolic process; protein polyubiquitination; positive regulation of transcription, DNA-templated; negative regulation of cell migration; regulation of mitotic cell cycle; histone H2B ubiquitination; positive regulation of histone H2B ubiquitination; histone ubiquitination; protein ubiquitination; histone monoubiquitination; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	56254
	109331
	ENSG00000155827
	ENSMUSG00000028309
	Q5VTR2
	Q5DTM8
	NM_019592
	NM_001163263; NM_182999; NM_001356401
	NP_062538
	NP_001156735; NP_892044; NP_001343330
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.^[5]^[6]^[7]^[8]^[9]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155827 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028309 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim J, Hake SB, Roeder RG (Dec 2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions". Mol Cell. 20 (5): 759–70. doi:10.1016/j.molcel.2005.11.012. PMID 16337599.
^ Wood A, Schneider J, Dover J, Johnston M, Shilatifard A (Sep 2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p". J Biol Chem. 278 (37): 34739–42. doi:10.1074/jbc.C300269200. PMID 12876294.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M (Oct 2008). "The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression". Genes Dev. 22 (19): 2664–76. doi:10.1101/gad.1703008. PMC 2559905. PMID 18832071.
^ Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K (Feb 2009). "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor". Mol Biol Cell. 20 (3): 757–68. doi:10.1091/mbc.E08-09-0983. PMC 2633391. PMID 19037095.
^ "Entrez Gene: RNF20 ring finger protein 20".

External links

RNF20+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155827 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028309 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16337599-5] Kim J, Hake SB, Roeder RG (Dec 2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions". Mol Cell. 20 (5): 759–70. doi:10.1016/j.molcel.2005.11.012. PMID 16337599.

[pmid12876294-6] Wood A, Schneider J, Dover J, Johnston M, Shilatifard A (Sep 2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p". J Biol Chem. 278 (37): 34739–42. doi:10.1074/jbc.C300269200. PMID 12876294.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid18832071-7] Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M (Oct 2008). "The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression". Genes Dev. 22 (19): 2664–76. doi:10.1101/gad.1703008. PMC 2559905. PMID 18832071.

[pmid19037095-8] Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K (Feb 2009). "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor". Mol Biol Cell. 20 (3): 757–68. doi:10.1091/mbc.E08-09-0983. PMC 2633391. PMID 19037095.

[entrez-9] "Entrez Gene: RNF20 ring finger protein 20".

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RNF20

See also

References

Further reading

External links