RNF216

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RNF216
Identifiers
Aliases RNF216, CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN, ring finger protein 216
External IDs MGI: 1344349 HomoloGene: 19442 GeneCards: RNF216
RNA expression pattern
PBB GE TRIAD3 218426 s at fs.png

PBB GE TRIAD3 218425 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019011
NM_207111
NM_207116

NM_080561
NM_207110

RefSeq (protein)

NP_996994
NP_996999

NP_542128.2
NP_996993.1
NP_542128
NP_996993

Location (UCSC) Chr 7: 5.62 – 5.78 Mb Chr 5: 142.99 – 143.11 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene.[3]

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.[3]

See also[edit]

Interactions[edit]

RNF216 has been shown to interact with TLR9[4] and RIPK1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: TRIAD3 TRIAD3 protein". 
  4. ^ Chuang, Tsung-Hsien; Ulevitch Richard J (May 2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. United States. 5 (5): 495–502. doi:10.1038/ni1066. ISSN 1529-2908. PMID 15107846. 
  5. ^ Chen, Danying; Li Xiaoyan; Zhai Zhonghe; Shu Hong-Bing (May 2002). "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation". J. Biol. Chem. United States. 277 (18): 15985–91. doi:10.1074/jbc.M108675200. ISSN 0021-9258. PMID 11854271. 

Further reading[edit]

External links[edit]