RSU1

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RSU1
Identifiers
Aliases RSU1, RSP-1, Ras suppressor protein 1
External IDs MGI: 103040 HomoloGene: 7521 GeneCards: RSU1
Gene location (Human)
Chromosome 10 (human)
Chr. Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for RSU1
Genomic location for RSU1
Band 10p13 Start 16,590,611 bp[1]
End 16,817,528 bp[1]
RNA expression pattern
PBB GE RSU1 201980 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012425
NM_152724

NM_009105

RefSeq (protein)

NP_036557
NP_689937

n/a

Location (UCSC) Chr 10: 16.59 – 16.82 Mb Chr 10: 13.08 – 13.27 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene.[5][6]

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.[6] RSU-1 has also been seen to act as a structural protein in integrin-mediated focal-adhesion complexes. It bind strongly to the protein PINCH.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148484 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026727 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Tsuda T, Cutler ML (Feb 1994). "Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10". Genomics. 18 (2): 461–2. doi:10.1006/geno.1993.1503. PMID 8288261. 
  6. ^ a b "Entrez Gene: RSU1 Ras suppressor protein 1". 

Further reading[edit]