Rani and Annadurai did not have any children of their own. They adopted Annadurai's elder sister's children. His sister, Rajamani Ammal, lived with them and looked after their home. Rajamani Ammal had four sons, and Annadurai and his wife Rani adopted all of them.
Rani was very supportive of Annadurai's work and political career. In the biography of C N Annadurai, written by Kannan R, it is mentioned that she would never disturb him while he was studying late at night, since she realised that his work was in the service of the nation. Even though she was frightened when he was arrested in 1938 for his role in the anti-Hindi agitation, she visited him frequently in jail.
When Annadurai became the Chief Minister, he found it necessary to create a home office at his residence to carry out his duties more efficiently. The government allowed him to furnish the office, and among the furniture he received was a sofa set. Rani wanted to keep the sofa said in the home and not the office room, but he did not allow her to do so – even though his office was in the same building as his home at this time.
After Annadurai's death, Rani Annadurai continued to be active in politics, for the A-DMK, DMK and also as an independent. She even contested elections for the Lok Sabha seat in Bangalore North constituency as an independent in 1977. She won 924 seats, but eventually lost to the Congress candidate.
- Kannan, R. (9 February 2010). ANNA: LIFE AND TIMES OF C.N. ANNADURAI. Penguin UK. ISBN 9788184753134.
- Ganesan, P. C. (14 August 2003). C N Annadurai. Publications Division Ministry of Information and Broadcasting Government of India. ISBN 9788123021706.
- Indian Recorder and Digest. 1 January 1974.
- Mirchandani, G.G. 32 Million Judges: An Analysis of 1977 Lok Sabha and State Elections in India. (New Delhi: Abhinav Publications, 2003)
- Venkatramanan, Geetha (14 July 2011). "Candid views". The Hindu. ISSN 0971-751X. Retrieved 26 November 2016.
- Data India. Press Institute of India. 1 January 1996.