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Region 2 or Region II can refer to:
- One of DVD region
- Region 2, Northwest Territories
- One of health regions of Canada managed by Horizon Health Network
- Former Region 2 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006
- One of Regions of Iran
- Antofagasta Region, Chile
- Cagayan Valley Region, Philippines
- ITU Region 2, consisting of the Americas
| disambiguation page lists articles associated with the title Region 2.
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