From Wikipedia, the free encyclopedia
  (Redirected from Rhes)
Jump to: navigation, search
RASD family, member 2
Symbols RASD2 ; MGC:4834; Rhes; TEM2
External IDs OMIM612842 MGI1922391 HomoloGene8628 GeneCards: RASD2 Gene
Species Human Mouse
Entrez 23551 75141
Ensembl ENSG00000100302 ENSMUSG00000034472
UniProt Q96D21 P63032
RefSeq (mRNA) NM_014310 NM_029182
RefSeq (protein) NP_055125 NP_083458
Location (UCSC) Chr 22:
35.54 – 35.55 Mb
Chr 8:
75.21 – 75.22 Mb
PubMed search [1] [2]

GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene.[1][2][3][4]

This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.[4]


  1. ^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988. 
  2. ^ Falk JD, Vargiu P, Foye PE, Usui H, Perez J, Danielson PE, Lerner DL, Bernal J, Sutcliffe JG (Oct 1999). "Rhes: A striatal-specific Ras homolog related to Dexras1". J Neurosci Res 57 (6): 782–8. doi:10.1002/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9. PMID 10467249. 
  3. ^ Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J (Jan 2004). "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene 23 (2): 559–68. doi:10.1038/sj.onc.1207161. PMID 14724584. 
  4. ^ a b "Entrez Gene: RASD2 RASD family, member 2". 

Further reading[edit]