Ribosyldihydronicotinamide dehydrogenase (quinone)

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dihydronicotinamide riboside quinone reductase
Ribosyldihydronicotinamide dehydrogenase dimer, Human
EC number1.10.99.2
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a ribosyldihydronicotinamide dehydrogenase (quinone) (EC is an enzyme that catalyzes the chemical reaction

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone

Thus, the two substrates of this enzyme are 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide and quinone, whereas its two products are 1-(beta-D-ribofuranosyl)nicotinamide and hydroquinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with other acceptors. The systematic name of this enzyme class is 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase. Other names in common use include NRH:quinone oxidoreductase 2, NQO2, NQO2, NAD(P)H:quinone oxidoreductase-2 (misleading), QR2, quinone reductase 2, N-ribosyldihydronicotinamide dehydrogenase (quinone), and NAD(P)H:quinone oxidoreductase2 (misleading).


  • LIAO S, DULANEY JT, WILLIAMS-ASHMAN HG (1962). "Purification and properties of a flavoprotein catalyzing the oxidation of reduced ribosyl nicotinamide". J. Biol. Chem. 237: 2981–7. PMID 14465018.
  • Zhao Q, Yang XL, Holtzclaw WD, Talalay P (1997). "Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1669–74. doi:10.1073/pnas.94.5.1669. PMC 19974. PMID 9050836.
  • S; Knox, R; Sun, XZ; Joseph, P; Jaiswal, AK; Zhang, D; Deng, PS; Chen, S (1997). "Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase". Arch. Biochem. Biophys. 347 (2): 221–8. doi:10.1006/abbi.1997.0344. PMID 9367528.
  • Jaiswal AK (1994). "Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression". J. Biol. Chem. 269 (20): 14502–8. PMID 8182056.