DeProspero attended West Virginia University, where he earned a bachelor's degree in physical education in 1959 and a master's degree in education in 1960. After serving in the United States Air Force from 1960 to 1963, he was employed by James Madison High School in Vienna, Virginia where he taught biological sciences and coached football and wrestling. In 1965, DeProspero joined the Secret Service where he moved up the ranks and held many positions. In 1981 after the attempted assassination of Ronald Reagan, he took charge of Reagan's security detail. The following year, DeProspero was appointed to head the Presidential Protective Division.
DeProspero devised several very important and innovative security measures during his time in the Secret Service that are used today: the "hospital agent" (stationing an agent at the nearest primary trauma hospital on a presidential movement), as well as the creation of metal detector checkpoints to screen every individual who could get a view of the president.
There is a feature-length documentary about Robert DeProspero in post-production called "The Man Behind the Suit: a documentary on Robert DeProspero".
- "Robert L. DeProspero (‘59 BS, 61 MA)". http://alumni.wvu.edu/. Morgantown, West Virginia: West Virginia University / West Virginia University Alumni Association. March 23, 2012. Retrieved July 24, 2012.
- Petro, Joseph; Robinson, Jeffrey (2005). Standing Next to History: An Agent's Life Inside the Secret Service. New York: Thomas Dunne Books/St. Martin's Press. pp. 141, 205–206. ISBN 9780312332228. Retrieved July 30, 2012.