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SNP: rs1799913
Name(s) A779C
Gene TPH1
Chromosome 11
Region Intron 7
External databases
Ensembl Human SNPView
dbSNP 1799913
HapMap 1799913
SNPedia 1799913
HgenetInfoDB 1799913
SzGene Meta-analysis

In genetics, rs1799913, also called A779C, is a gene variation—a single nucleotide polymorphism (SNP)— in the TPH1 gene. It is located in intron 7.[1]

The SNP association with schizophrenia has been examined in several studies, though as of 2007 with no definitive conclusion.[2]

One study has found that the SNP may be associated with heroin addiction.[3]

A218C (rs1800532) is another SNP in the same intron in the same gene.[1]


  1. ^ a b D. A. Nielsen, G. L. Jenkins, K. M. Stefanisko, K. K. Jefferson & D. Goldman (April 1997). "Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7". Brain Research. Molecular Brain Research. 45 (1): 145–148. PMID 9105682. doi:10.1016/S0169-328X(96)00304-X. 
  2. ^ P. G. Sand (November 2007). "Comments on the paper by D. Li and L. He: Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia". Human Genetics. 122 (3–4): 409–411. PMID 17653577. doi:10.1007/s00439-007-0383-6. 
  3. ^ David A. Nielsen, Sandra Barral, Dmitri Proudnikov, Scott Kellogg, Ann Ho, Jurg Ott & Mary Jeanne Kreek (March 2008). "TPH2 and TPH1: association of variants and interactions with heroin addiction". Behavior Genetics. 38 (2): 133–50. PMID 18181017. doi:10.1007/s10519-007-9187-7.