S-(hydroxymethyl)glutathione synthase

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S-(hydroxymethyl)glutathione synthase
Identifiers
EC number 4.4.1.22
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a S-(hydroxymethyl)glutathione synthase (EC 4.4.1.22) is an enzyme that catalyzes the chemical reaction

S-(hydroxymethyl)glutathione glutathione + formaldehyde

Hence, this enzyme has one substrate, S-(hydroxymethyl)glutathione, and two products, glutathione and formaldehyde.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming). Other names in common use include glutathione-dependent formaldehyde-activating enzyme, Gfa, and S-(hydroxymethyl)glutathione formaldehyde-lyase. This enzyme participates in methane metabolism.

References[edit]

  • Goenrich M; Bartoschek S; Hagemeier CH; Griesinger C; Vorholt JA (2002). "A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy". J. Biol. Chem. 277 (5): 3069–72. doi:10.1074/jbc.C100579200. PMID 11741920.