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S12, S.XII, S-12 or S.12 may refer to:

In military 
  • SABCA S-12, a Belgian aircraft
  • SIAI S.12, an Italian 1910s reconnaissance flying-boat
  • SPAD S.XII, a French single-seat biplane fighter aircraft of the First World War
  • USS S-12 (SS-117), a 1921 S-class submarine of the United States Navy
In transportation 
In science and academia 

S12 may refer to :