Secretagogin

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SCGN
Identifiers
AliasesSCGN, CALBL, DJ501N12.8, SECRET, SEGN, setagin, secretagogin, EF-hand calcium binding protein
External IDsMGI: 2384873 HomoloGene: 5088 GeneCards: SCGN
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SCGN
Genomic location for SCGN
Band6p22.2Start25,652,201 bp[1]
End25,701,783 bp[1]
RNA expression pattern
PBB GE SCGN 205697 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006998

NM_145399

RefSeq (protein)

NP_008929

NP_663374

Location (UCSC)Chr 6: 25.65 – 25.7 MbChr 13: 23.95 – 23.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Secretagogin is a protein that in humans is encoded by the SCGN gene.[5][6]

Function[edit]

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation.[6] This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079689 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021337 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Wagner L; Oliyarnyk O; Gartner W; Nowotny P; Groeger M; Kaserer K; Waldhausl W; Pasternack MS (Sep 2000). "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein". J Biol Chem. 275 (32): 24740–51. doi:10.1074/jbc.M001974200. PMID 10811645.
  6. ^ a b "Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein".

Further reading[edit]