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Aliases SEMA3C, SEMAE, SemE, semaphorin 3C
External IDs MGI: 107557 HomoloGene: 36201 GeneCards: SEMA3C
RNA expression pattern
PBB GE SEMA3C 203788 s at fs.png

PBB GE SEMA3C 203789 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 80.74 – 80.92 Mb Chr 5: 17.57 – 17.73 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene.[3][4][5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561. 
  4. ^ Mangasser-Stephan K, Dooley S, Welter C, Mutschler W, Hanselmann RG (May 1997). "Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display". Biochemical and Biophysical Research Communications. 234 (1): 153–6. doi:10.1006/bbrc.1997.6607. PMID 9168980. 
  5. ^ "Entrez Gene: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C". 

Further reading[edit]

  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101. 
  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348. 
  • Yamada T, Endo R, Gotoh M, Hirohashi S (December 1997). "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14713–8. doi:10.1073/pnas.94.26.14713. PMC 25101Freely accessible. PMID 9405678. 
  • Galani E, Sgouros J, Petropoulou C, Janinis J, Aravantinos G, Dionysiou-Asteriou D, Skarlos D, Gonos E (2002). "Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients". Anticancer Research. 22 (4): 2275–80. PMID 12174914. 
  • Rieger J, Wick W, Weller M (June 2003). "Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins". Glia. 42 (4): 379–89. doi:10.1002/glia.10210. PMID 12730958. 
  • Miller LE, Weidler C, Falk W, Angele P, Schaumburger J, Schölmerich J, Straub RH (April 2004). "Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis". Arthritis and Rheumatism. 50 (4): 1156–63. doi:10.1002/art.20110. PMID 15077297. 
  • Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M, Hrabé de Angelis M, Seliger B (April 2005). "Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis". International Journal of Cancer. 114 (4): 590–7. doi:10.1002/ijc.20798. PMID 15609325. 
  • Herman JG, Meadows GG (May 2007). "Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells". International Journal of Oncology. 30 (5): 1231–8. doi:10.3892/ijo.30.5.1231. PMID 17390026.