SENP6

SENP6
Identifiers
Aliases	SENP6, SSP1, SUSP1, SUMO1/sentrin specific peptidase 6, SUMO specific peptidase 6
External IDs	OMIM: 605003; MGI: 1922075; HomoloGene: 9196; GeneCards: SENP6; OMA:SENP6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q14.1 Start 75,601,509 bp End 75,718,281 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E1 Start 80,066,903 bp End 80,144,953 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone gastric mucosa right uterine tube sural nerve left ovary ganglionic eminence right ovary body of uterus left lobe of thyroid gland Top expressed in genital tubercle tail of embryo ventricular zone zygote granulocyte ganglionic eminence gastric mucosa left lung lobe mucous cell of stomach epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type peptidase activity protein binding hydrolase activity SUMO-specific endopeptidase activity Cellular component nucleus nucleoplasm cytosol cytoplasm Biological process protein desumoylation protein modification by small protein removal regulation of spindle assembly protein sumoylation proteolysis regulation of kinetochore assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26054 215351 Ensembl ENSG00000112701 ENSMUSG00000034252 UniProt Q9GZR1 Q6P7W0 RefSeq (mRNA) NM_001100409 NM_001304792 NM_015571 NM_146003 NM_001311110 RefSeq (protein) NP_001093879 NP_001291721 NP_056386 NP_001298039 NP_666115 Location (UCSC) Chr 6: 75.6 – 75.72 Mb Chr 9: 80.07 – 80.14 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene.

See also

• small ubiquitin-related modifier 1

Further reading

• Mikolajczyk J; Drag M; Békés M; Cao JT; Ronai Z; Salvesen GS. (2007). "Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs". J. Biol. Chem. 282 (36): 26217–24. doi:10.1074/jbc.M702444200. PMID 17591783.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Drag M; Mikolajczyk J; Krishnakumar IM; Huang Z; Salvesen GS. (2008). "Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family". Biochem J. 409 (2): 461–9. doi:10.1042/BJ20070940. PMID 17916063.