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Available structures
PDBOrtholog search: PDBe RCSB
AliasesSEPSECS, LP, PCH2D, SLA, SLA/LP, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
External IDsMGI: 1098791 HomoloGene: 15031 GeneCards: SEPSECS
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for SEPSECS
Genomic location for SEPSECS
Band4p15.2Start25,120,014 bp[1]
End25,160,449 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 4: 25.12 – 25.16 MbChr 5: 52.64 – 52.67 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

O-phosphoseryl-tRNA(Sec) selenium transferase is an enzyme that in humans is encoded by the SEPSECS gene.[5][6][7][8][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109618 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029173 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Xu XM, Mix H, Carlson BA, Grabowski PJ, Gladyshev VN, Berry MJ, Hatfield DL (Dec 2005). "Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery". J. Biol. Chem. 280 (50): 41568–75. doi:10.1074/jbc.M506696200. PMID 16230358.
  6. ^ Costa M, Rodríguez-Sánchez JL, Czaja AJ, Gelpí C (Aug 2000). "Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients with type-1 autoimmune hepatitis". Clin. Exp. Immunol. 121 (2): 364–74. doi:10.1046/j.1365-2249.2000.01280.x. PMC 1905695. PMID 10931155.
  7. ^ Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D (Dec 2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18923–7. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.
  8. ^ Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL (Apr 2007). "Biosynthesis of selenocysteine on its tRNA in eukaryotes". PLoS Biol. 5 (1): e4. doi:10.1371/journal.pbio.0050004. PMC 1717018. PMID 17194211.
  9. ^ "Entrez Gene: SLA/LP soluble liver antigen/liver pancreas antigen".

Further reading[edit]

  • Herkel J, Heidrich B, Nieraad N, Wies I, Rother M, Lohse AW (2002). "Fine specificity of autoantibodies to soluble liver antigen and liver/pancreas". Hepatology. 35 (2): 403–8. doi:10.1053/jhep.2002.30699. PMID 11826415.
  • Volkmann M, Martin L, Bäurle A, Heid H, Strassburg CP, Trautwein C, Fiehn W, Manns MP (2001). "Soluble liver antigen: isolation of a 35-kd recombinant protein (SLA-p35) specifically recognizing sera from patients with autoimmune hepatitis". Hepatology. 33 (3): 591–6. doi:10.1053/jhep.2001.22218. PMID 11230739.
  • Wies I, Brunner S, Henninger J, Herkel J, Kanzler S, Meyer zum Büschenfelde KH, Lohse AW (2000). "Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis". Lancet. 355 (9214): 1510–5. doi:10.1016/S0140-6736(00)02166-8. PMID 10801173.