From Wikipedia, the free encyclopedia
Jump to: navigation, search
Aliases SEPT8, SEP2, septin 8
External IDs MGI: 894310 HomoloGene: 57205 GeneCards: SEPT8
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)
Location (UCSC) Chr 5: 132.75 – 132.81 Mb Chr 11: 53.52 – 53.55 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Septin-8 is a protein that in humans is encoded by the SEPT8 gene.[3][4][5]


SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.[5]


SEPT8 has been shown to interact with PFTK1[6] and SEPT5.[7][8]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502. 
  4. ^ Frazer KA, Ueda Y, Zhu Y, Gifford VR, Garofalo MR, Mohandas N, Martin CH, Palazzolo MJ, Cheng JF, Rubin EM (May 1997). "Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region". Genome Research. 7 (5): 495–512. doi:10.1101/gr.7.5.495. PMID 9149945. 
  5. ^ a b "Entrez Gene: SEPT8 septin 8". 
  6. ^ Yang T, Gao YK, Chen JY (July 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 520–5. PMID 12098780. 
  7. ^ Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369. 
  8. ^ Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1-3): 169–72. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038. 

Further reading[edit]