SF3A1

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SF3A1
Protein SF3A1 PDB 1we7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SF3A1, PRP21, PRPF21, SAP114, SF3A120, splicing factor 3a subunit 1
External IDs MGI: 1914715 HomoloGene: 4294 GeneCards: SF3A1
RNA expression pattern
PBB GE SF3A1 216457 s at fs.png

PBB GE SF3A1 201357 s at fs.png

PBB GE SF3A1 201356 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005877
NM_001005409

NM_026175

RefSeq (protein)

NP_005868

NP_080451.4
NP_080451

Location (UCSC) Chr 22: 30.33 – 30.36 Mb Chr 11: 4.16 – 4.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.[3][4]

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.[4]

Interactions[edit]

SF3A1 has been shown to interact with SF3A3[5][6] and CDC5L.[7]

References[edit]

Further reading[edit]

External links[edit]