SH2D2A

SH2D2A
Identifiers
Aliases	SH2D2A, F2771, SCAP, TSAD, VRAP, SH2 domain containing 2A
External IDs	OMIM: 604514; MGI: 1351596; HomoloGene: 2958; GeneCards: SH2D2A; OMA:SH2D2A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,816,848 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	87,763,029 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; testicle; ; blood; ; gonad; ; spleen; ; appendix; ; epithelium of colon; ; lymph node; ; apex of heart; ; upper lobe of left lung;
	Top expressed in
	thymus; ; blood; ; embryo; ; mesenteric lymph nodes; ; spleen; ; subcutaneous adipose tissue; ; hematopoietic cell; ; granulocyte; ; jejunum; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein binding;
Cellular component	cytoplasm; cytosol;
Biological process	multicellular organism development; cell differentiation; vascular endothelial growth factor receptor signaling pathway; cell population proliferation; angiogenesis; signal transduction; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9047
	27371
	ENSG00000027869
	ENSMUSG00000028071
	Q9NP31
	Q9QXK9
	NM_001161441; NM_001161442; NM_001161443; NM_001161444; NM_003975
	NM_001025571; NM_021309
	NP_001154913; NP_001154914; NP_001154915; NP_001154916; NP_003966
	NP_001020742; NP_067284
	Wikidata
View/Edit Human	View/Edit Mouse

SH2 domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene.^[5]^[6]

Interactions

SH2D2A has been shown to interact with MAP3K2.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000027869 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028071 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Spurkland A; Brinchmann JE; Markussen G; Pedeutour F; Munthe E; Lea T; Vartdal F; Aasheim HC (March 1998). "Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites". J Biol Chem. 273 (8): 4539–46. doi:10.1074/jbc.273.8.4539. PMID 9468509.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: SH2D2A SH2 domain protein 2A".
^ Sun, W; Kesavan K; Schaefer B C; Garrington T P; Ware M; Johnson N L; Gelfand E W; Johnson G L (February 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". J. Biol. Chem. 276 (7). United States: 5093–100. doi:10.1074/jbc.M003719200. ISSN 0021-9258. PMID 11073940. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)