SHC2

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SHC2
Identifiers
Aliases SHC2, SCK, SHCB, SLI, SHC adaptor protein 2
External IDs MGI: 106180 HomoloGene: 19127 GeneCards: SHC2
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SHC2
Genomic location for SHC2
Band 19p13.3 Start 416,583 bp[1]
End 460,996 bp[1]
RNA expression pattern
PBB GE SHC2 213464 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012435

NM_001024539

RefSeq (protein)

NP_036567

NP_001019710

Location (UCSC) Chr 19: 0.42 – 0.46 Mb Chr 10: 79.62 – 79.64 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.[5][6][7]


Interactions[edit]

SHC2 has been shown to interact with Kinase insert domain receptor.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129946 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020312 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kavanaugh WM; Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science. 266 (5192): 1862–5. doi:10.1126/science.7527937. PMID 7527937. 
  6. ^ Nakamura T; Muraoka S; Sanokawa R; Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002. 
  7. ^ "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2". 
  8. ^ Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (Apr 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. England. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983Freely accessible. PMID 10749680. 

Further reading[edit]