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Available structures
PDB Ortholog search: PDBe RCSB
Aliases SIAH2, hSiah2, siah E3 ubiquitin protein ligase 2
External IDs MGI: 108062 HomoloGene: 21053 GeneCards: SIAH2
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SIAH2
Genomic location for SIAH2
Band 3q25.1 Start 150,741,127 bp[1]
End 150,763,477 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 150.74 – 150.76 Mb Chr 3: 58.67 – 58.69 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase SIAH2 is an enzyme that in humans is encoded by the SIAH2 gene.[5][6]


This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.[6]


SIAH2 has been shown to interact with PEG10,[7] Synaptophysin,[8] PEG3[9] and VAV1.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181788 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036432 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER (October 1997). "Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway". Genes & Development. 11 (20): 2701–14. doi:10.1101/gad.11.20.2701. PMC 316613Freely accessible. PMID 9334332. 
  6. ^ a b "Entrez Gene: SIAH2 seven in absentia homolog 2 (Drosophila)". 
  7. ^ Okabe H, Satoh S, Furukawa Y, Kato T, Hasegawa S, Nakajima Y, Yamaoka Y, Nakamura Y (June 2003). "Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1". Cancer Research. 63 (12): 3043–8. PMID 12810624. 
  8. ^ Wheeler TC, Chin LS, Li Y, Roudabush FL, Li L (March 2002). "Regulation of synaptophysin degradation by mammalian homologues of seven in absentia". The Journal of Biological Chemistry. 277 (12): 10273–82. doi:10.1074/jbc.M107857200. PMID 11786535. 
  9. ^ Relaix F, Wei XJ, Li W, Pan J, Lin Y, Bowtell DD, Sassoon DA, Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 97 (5): 2105–10. doi:10.1073/pnas.040378897. PMC 15761Freely accessible. PMID 10681424. 
  10. ^ Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N (May 1999). "hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways". Molecular and Cellular Biology. 19 (5): 3798–807. PMC 84217Freely accessible. PMID 10207103. 

Further reading[edit]