SLC22A13

SLC22A13
Identifiers
Aliases	SLC22A13, OAT10, OCTL1, OCTL3, ORCTL-3, ORCTL3, solute carrier family 22 member 13
External IDs	OMIM: 604047; MGI: 2143107; HomoloGene: 3140; GeneCards: SLC22A13; OMA:SLC22A13 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	38,278,757 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	119,038,164 bp
RNA expression pattern
	Top expressed in
	renal cortex; ; stromal cell of endometrium; ; metanephros; ; human kidney; ; apex of heart; ; muscle of thigh; ; blood; ; mucosa of transverse colon; ; cerebellum; ; cerebellar cortex;
	Top expressed in
	right kidney; ; human kidney; ; proximal tubule; ; proximal straight tubule; ; morula; ; ganglion of vagus nerve; ; thyroid gland; ; embryo; ; convoluted tubule; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter activity; organic cation transmembrane transporter activity; nicotinate transmembrane transporter activity; inorganic anion exchanger activity; sodium-independent organic anion transmembrane transporter activity;
Cellular component	integral component of plasma membrane; apical plasma membrane; membrane; extracellular exosome; integral component of membrane; plasma membrane;
Biological process	nicotinate transport; transmembrane transport; urate transport; organic cation transport; NAD biosynthesis via nicotinamide riboside salvage pathway; inorganic anion transport; sodium-independent organic anion transport;
	Sources:Amigo / QuickGO
Orthologs
	9390
	102570
	ENSG00000172940
	ENSMUSG00000074028
	Q9Y226
	Q6A4L0
	NM_004256
	NM_133980
	NP_004247
	NP_598741
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene. ^[5]

Function

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172940 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074028 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Solute carrier family 22 member 13". Retrieved 2017-10-05.

Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, Burckhardt G (2008). "Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)". J. Biol. Chem. 283 (24): 16332–41. doi:10.1074/jbc.M800737200. PMID 18411268.
Irshad S, Mahul-Mellier AL, Kassouf N, Lemarie A, Grimm S (2009). "Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers". Cell Death Differ. 16 (6): 890–8. doi:10.1038/cdd.2009.21. PMC 2683172. PMID 19282870.
Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolić I, Koepsell H, Brockmöller J (2009). "The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin". Clin. Pharmacol. Ther. 86 (3): 299–306. doi:10.1038/clpt.2009.92. PMID 19536068. S2CID 8583867.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Schulz C, Fork C, Bauer T, Golz S, Geerts A, Schömig E, Gründemann D (2014). "SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct". Biochem. J. 457 (2): 243–51. doi:10.1042/BJ20130654. PMID 24147638.
AbuAli G, Chaisaklert W, Stelloo E, Pazarentzos E, Hwang MS, Qize D, Harding SV, Al-Rubaish A, Alzahrani AJ, Al-Ali A, Sanders TA, Aboagye EO, Grimm S (2015). "The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis". Oncogene. 34 (13): 1718–28. doi:10.1038/onc.2014.93. PMC 4119473. PMID 24769897.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172940 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074028 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Solute carrier family 22 member 13". Retrieved 2017-10-05.

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Function

References

Further reading