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Solute carrier family 46 (folate transporter), member 1
Symbols SLC46A1 ; G21; HCP1; PCFT
External IDs OMIM611672 MGI1098733 HomoloGene41693 ChEMBL: 1795188 GeneCards: SLC46A1 Gene
RNA expression pattern
PBB GE PCFT gnf1h08403 at tn.png
More reference expression data
Species Human Mouse
Entrez 113235 52466
Ensembl ENSG00000076351 ENSMUSG00000020829
UniProt Q96NT5 Q6PEM8
RefSeq (mRNA) NM_001242366 NM_026740
RefSeq (protein) NP_001229295 NP_081016
Location (UCSC) Chr 17:
28.39 – 28.41 Mb
Chr 11:
78.47 – 78.47 Mb
PubMed search [1] [2]

Solute carrier family 46 (folate transporter), member 1 (SLC46A1) also known as proton-coupled folate transporter (PCFT), is a protein which in humans is encoded by the SLC46A1 gene.[1][2][3]


SLC46A1 is responsible for the intestinal uptake of folate.[4]


  1. ^ "Entrez Gene: PCFT proton-coupled folate transporter". 
  2. ^ Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT (September 2005). "Identification of an intestinal heme transporter". Cell 122 (5): 789–801. doi:10.1016/j.cell.2005.06.025. PMID 16143108. 
  3. ^ Sharma S, Dimasi D, Bröer S, Kumar R, Della NG (April 2007). "Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium". Exp. Cell Res. 313 (6): 1251–9. doi:10.1016/j.yexcr.2007.01.019. PMID 17335806. 
  4. ^ Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H (August 2007). "Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter". J. Pharmacol. Exp. Ther. 322 (2): 469–76. doi:10.1124/jpet.107.122606. PMID 17475902. 

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