SLC46A1

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SLC46A1
Identifiers
Aliases SLC46A1, G21, HCP1, PCFT, solute carrier family 46 member 1
External IDs MGI: 1098733 HomoloGene: 41693 GeneCards: SLC46A1
Targeted by Drug
indomethacin, methotrexate[1]
RNA expression pattern
PBB GE PCFT gnf1h08403 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242366
NM_080669

NM_026740

RefSeq (protein)

NP_001229295
NP_542400

NP_081016.2
NP_081016

Location (UCSC) Chr 17: 28.39 – 28.41 Mb Chr 11: 78.47 – 78.47 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 46 (folate transporter), member 1 (SLC46A1) also known as proton-coupled folate transporter (PCFT), is a protein which in humans is encoded by the SLC46A1 gene.[4][5][6]

Function[edit]

SLC46A1 is responsible for the intestinal uptake of folate.[7]

References[edit]

  1. ^ "Drugs that physically interact with Solute carrier family 46 member 1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: PCFT proton-coupled folate transporter". 
  5. ^ Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT (September 2005). "Identification of an intestinal heme transporter". Cell. 122 (5): 789–801. doi:10.1016/j.cell.2005.06.025. PMID 16143108. 
  6. ^ Sharma S, Dimasi D, Bröer S, Kumar R, Della NG (April 2007). "Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium". Exp. Cell Res. 313 (6): 1251–9. doi:10.1016/j.yexcr.2007.01.019. PMID 17335806. 
  7. ^ Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H (August 2007). "Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter". J. Pharmacol. Exp. Ther. 322 (2): 469–76. doi:10.1124/jpet.107.122606. PMID 17475902. 

Further reading[edit]


External links[edit]